Hetionet: an integrative network of disease

Daniel Himmelstein is the creator of Hetionet – an integrative network of biology, disease, and pharmacology.
‘hetnet’ is actually a word coined by Daniel to describe networks with many types of relationships

Hetionet is a hetnet — network with multiple node and edge (relationship) types — which encodes biology. The hetnet was designed for Project Rephetio, which aims to systematically identify why drugs work and predict new therapies for drugs.

Version 1.0 contains 47,031 nodes of 11 types and 2,250,197 relationships of 24 types. This repository is currently only a download location for Hetionet. The data integration and hetnet creation occurs in a separate repository (dhimmel/integrate) and is imported to this repository by import.ipynb.

Network Description

describe contains summary statistics on the hetnet. See describe/nodes/metanodes.tsv for details on the node types in the hetnet. See describe/edges/metaedges.tsv for details on the edge types.

Below, we provide two hetnet visualizations. Panel A shows the metagraph (graph of types) for Hetionet. Panel B shows the actual hetnet with nodes laid out in circles by type. Color denotes edge type.

Hetionet v1.0 visualizations



All original content in this repository is released as CC0. However, the hetnet integrates data from many resources and users should consider the licensing of each source (see this table). We apply a license attribute on a per node and per edge basis for sources with defined licenses. However, some resources don’t provide any license, so for those we’ve requested permission. More information is available on Thinklab.



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